Terminology: Acute Toxicity Test (Mandatory SIAA test item)

For acute toxicity testing, there are oral toxicity tests, percutaneous toxicity tests, and respiratory toxicity tests. As a rule, the type of test conducted is selected based on the type of exposure the test substance may have.
This test administers a single dose or a repeated dose of the test substance to the test animals over a short period of time.
The symptoms, weight changes, physiological changes are examined at this time to elucidate the qualitative and quantitative toxicity characteristics of the test substance.

[Test Method]
Using rats as test animals, 5000 mg/kg of the test substance was administered orally or 2000 mg/kg was administered subcutaneously. These tests were administered in compliance with the Pharmaceutical Affairs Bureau Bulletin 313: Standards for Good Laboratory Practices in Pharmaceutical Products Safety Tests.
Anything over 1500 mg/kg at LD₅₀ is deemed a substance with low toxicity.

[Test Results for Zeomic]
No test animal showed weight decrease nor did even a single case of death occur with the oral administration test results. The LD₅₀ was determined to be 5000 mg/kg or higher. Incidentally, the LD₅₀ of sodium chloride is 3000 mg/kg. The LD₅₀ for percutaneous administration was 2000 mg/kg or higher.

Terminology: Acute Toxicity Test (Mandatory SIAA test item)

Pertaining to Acute Toxicity Test (Mandatory SIAA test item)

Related information