- Zeomic and antimicrobial-related terminology
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Terminology: Dog Sub-chronic Toxicity Test
The objective of this test is to examine the sub-chronic toxicity of a test substance not with rats, which are a member of Rodentia, but with dogs, which have similar metabolic functions to those of humans in order to examine the occurrence of toxic reactivity when a test substance is administered repeatedly to a test animal for a relatively short period (3 months).
[Test Method]
A test was conducted with beagles as test animals by administering oral doses of 0, 10, 50 and 250 mg/kg-bw/day for 90 days. The organs and their tissues of all test animals were observed from a histopathological aspect and for morphological changes in such organs as the stomach, duodenum, appendix, rectum, and kidneys for evaluation as per
OECD 409, "Repeated Dose 90-day Oral Toxicity Study in Non-Rodents," EC Directive 87/302/EEC, "90-day Repeated Oral Dose Study using Non-rodent species."
[Test Results for Zeomic]
As a result, no morphological changes were observed in the 10mg/kg-bw/day and 50mg/kg-bw/day groups, and the no-observed adverse effect level (NOAEL) was determined at 50mg/kg-bw/day.
Pertaining to Dog Sub-chronic Toxicity Test
