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Functions of silver-base inorganic antimicrobial agent "Zeomic"

Antimicrobial function

Odor-eliminating function

Antiviral function

Zeomic antimicrobial function

As more and more emphasis is placed on the peace-of-mind and safety of people, the functions and roles demanded of antimicrobial agents are diversifying. In 1984, Sinanen Zeomic was the first in the world to succeed at commercializing Zeomic, a silver-base inorganic antimicrobial agent. With its superior antimicrobial effect and high safety factor, Zeomic is used in a broad range of fields, from food packaging and home construction materials close to the everyday life of people, and to medical, supporting a safe and comfortable lifestyle.

For richer days and better comfort. We will continue to transmit antimicrobial culture connecting the future to the world.

What is "antimicrobial"?

According to JIS Z 2801(ISO22196), antimicrobial is defined as “A state where the growth of bacteria in a product’s surface is inhibited.”

Antimicrobial

To create a condition in which bacteria does not survive easily whereby,even if germs do adhere to the subject,they will only live for a certain period of time or they will be unable to grow. To inhibit the growth of bacteria,rather than kill or decrease their number.

Sterilization

To completely kill and remove all proliferative bacteria such as microbes. This terminology is mainly used when referring to medical apparatus used in surgery.

Disinfection

To kill microbes with no defined subject or extent.

Sanitization

To kill pathogenic organisms,reducing their number to an extent that is not harmful,and making them harmless by removing their infectability.

Elimination of bacteria

To reduce the number of microbes in objects,liquid or restricted spaces and increase cleanliness.

Zeomic's antimicrobial mechanism

Zeomic’s antimicrobial mechanism works by inhibiting the function of enzymes in the metabolic systems of microbes.

  1. The silver ions from Zeomic impregnate the microbe surface and are then absorbed by the cells through active transfer.
  2. The silver ions react with several metabolic enzymes within the metabolic system of the microbes.
  3. The activity of these enzymes is hindered and the growth of microbes is inhibited.

Antimicrobial spectrum

The silver ions included in Zeomic are what gives the agent its antimicrobial effect on a wide range of microbes including gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa,gram-positive bacteria such as Staphylococcus aureus and MRSA,and molds such as Aspergillus niger and Penicillium.

MIC (Minimum Inhibitory Concentration) Measurement Results

Bacteria type

Tested strains MIC(ppm)
Proteus vulgaris ATCC 13315 16
Escherichia coli NBRC3301 62.5
Pseudomonas aeruginosa IID P-1 62.5
Vibrio parahaemolyticus NBRC 12711 62.5
Salmonella gallinarum NBRC3163 125
Enterobacter aerogenes NBRC13534 125
Bacillus cereus var mycoides ATCC11778 125
Streptococcus faecalis ATCC8043 125
Escherichia coli O-157:H7 125
Staphylococcus aureus ATCC6538P 250
Methicillin-Resistant Staphylococcus aureus 250
Bacillus subtilis ATCC6633 250
Methylobacterium mesophilicum NBRC15688 500
Micrococcus flavus ATCC 10240 500
Moraxella osloensis ATCC 19976 200

Yeast type

Tested strains MIC(ppm)
Saccharomyces cerevisiae NBRC1950 250
Candida albicans NBRC1594 250
Rhodotorula glutinis NBRC 1125 500

Mold type

Tested strains MIC(ppm)
Aspergillus niger NBRC 4407 500
Aureobasidium pullulans NBRC6353 500
Chaetomium globosum ATCC 6205 500
Gliocladium virens NBRC6355 500
Penicillium funiculosum NBRC6345 500
Cladosporium herbarum NBRC4495 500
Penicillium citrinum NBRC 7784 500
Alternaria alternata NBRC 31188 500
Fusarium moniliforme NHL F-616s 500
Fusarium oxysporum NHL F-5009 1,000
Aspergillus flavus ATCC 10836 1,000
Geotrichum candidum 1,000
Mucor racemosus NBRC 4581 500
Myrothecium verrucaria NBRC 6113 250
Penicillium nigricans NBRC6103 1,000
Paecilomyces varioti 1,000
Rhizopus nigricans 250
Trichoderma viride NBRC 31137 1,000
Curvularia trifolii NBRC 7276 250
Trichophyton mentagrophytes NBRC 6202 500

MIC : Minimum Inhibitory Concentration
MIC is defined as the lowest concentration (ppm) of the subject antimicrobial,including an appropriate dilution. At this concentration or higher,the microbe being tested will not grow. The MIC value assumes that the bacteria are in a bacteriostatic condition.

MIC is not equivalent to the amount of antimicrobial agent which needs to be attached to the product (it is one scale used to compare effectiveness)

Acquired Zeomic resistance experiment results

In an experiment to test the acquired resistance to Zeomic,as a result of repeated subculture of Staphylococcus aureus,methicillin-resistants Staphylococcus aureus and Pseudomonas aeruginos,there was hardly any fluctuation in the minimal inhibitory concentration.

Results of Acquiring Antimicrobial Resistance Test against Zeomic (Concentration: ppm)

Generation time Staphylococcus aureus MRSA Pseudomonas aeruginosa
1 250 500 200
2 500 500 200
3 250 250 100
4 250 250 200
5 250 250 100
6 250 250 100
7 250 250 100
8 250 250 200
9 250 250 100
10 250 250 200

Antimicrobial effects against MRSA of a polyester cloth containing Zeomic

Sample

  1. Cotton cloth (control)
  2. Fabric using 35% antimicrobial polyester
  3. Fabric using 65% antimicrobial polyester
  4. Fabric using 65% antimicrobial polyester

Method

MRSA liquid (104cfu/ml) was smeared on normal agar medium, and then a polyester cloth containing Zeomic (cloth mixed with antimicrobial polyester) was attached. This shows the culture medium surface with the cloth removed after a 24-hour culturing period at 37℃.

Result

According to the experiment results,the MRSA on the surface of the polyester cloth containing Zeomic are dead.
MRSA is one of the main bacteria causing hospital infections. The fact that Zeomic has been proven to possess antimicrobial effects on MRSA suggests its validity in antimicrobial countermeasures within medical facilities.

Method

A cloth fragment was soaked in MRSA liquid (104cfu/ml),removed,and then left for 6 hours. After this,the culture media where the sample was brought in contact with normal agar medium was cultured for 24 hours at 37˚C.

Result

The growth of bacteria on the polyester cloth containing Zeomic was inhibited after 6 hours of contact.

Antimicrobial performance test data

Zeomic is stabilized by silver ions displaying antimicrobial ability cohered to its fundamental structure. There is hardly any dissolution caused by water,solvent,etc. and antimicrobial effects are maintained for a prolonged period of time.

Plastics

An agent is defined as effective when the antibacterialactivity value is 2.0 or more (99% or higher death rate).

PP Plate (Test method JIS Z2801:2010)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 9.3×102 1.3×105
0.5% Zeomic Not detected >3.1 Not detected >5.3
ABS Plate (Test method JIS Z2801:2010)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 8.7×104 1.8×106
0.5% Zeomic Not detected >5.1 Not detected >6.5
PE Film (Test method JIS Z2801:2010)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 2.9×103 5.8×105
0.5% Zeomic Not detected >3.6 Not detected >5.9
PE Cutting Board (Test method JIS Z2801:2000E*scherichia Coli)
Test sample After 1 month of use After 4 years of use
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 4.3×105 7.1×105
0.5% Zeomic Not detected >4.6 Not detected >4.8

Paint

An agent is defined as effective when the antibacterialactivity value is 2.0 or more (99% or higher death rate).

Acrylic Paint (Test method JIS Z2801:2010)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 1.6×103 4.1×103
0.5% Zeomic Not detected >3.4 Not detected >3.8
Powder Paint (Test method JIS Z2801:2010)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Antibacterial activity value Viable bacteria count Antibacterial activity value
No additives 4.4×104 3.1×105
0.5% Zeomic Not detected >4.8 Not detected >5.6

Fiber

Polyester cotton knead master batch(JIS L 1902: 2002)
Test sample Staphylococcus aureus
Viable bacteria count Bactericidal activity value
Untreated 2.1×106
Product containing 2.0% Zeomic Not detected >2.93
Zeomic: 2.0% Cotton = 50/50 Not detected >2.93
Cotton (Test method JIS L1902:2008)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Bacteriostatic activity Viable bacteria count Bacteriostatic activity
Untreated 2.5×106 2.1×107
0.5% Zeomic Not detected >5.09 Not detected >6.02
PP non-woven fabric post-processed product (JIS L 1902:2002)
Test sample Staphylococcus aureus Escherichia coli
Viable bacteria count Bactericidal activity value Viable bacteria count Bactericidal activity value
Untreated 3.7×106 5.5×107
Product processed with 0.5g/m2 Zeomic Not detected >3.11 Not detected >3.11

Zeomic's deodorizing function

By inhibiting the growth of bacteria,Zeomic also inhibits the gases generated by the metabolisms of bacteria,thus is anticipated to have a deodorizing effect.

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