Terminology: Rabbit Eye Irritation Test

The objective of this test is to examine the toxicity of a test substance to eyes--both qualitatively and quantitatively (lethal dose). It deals with the primary irritation that causes reversible inflammatory changes involving no immunity-mediated mechanism. When it is anticipated that the administration of a solid form of the test substance would cause obvious physical irritation to the eyes, this test also allows extracts to be administered from the test substance, in order to evaluate its chemical stimulation.

[Test Method]
A test was conducted with rabbits as test animals. A 5% Zeomic suspension was administered into one eye as per FDA (#163, August 1978) method.

[Test Results for Zeomic]
As a result, it was determined that Zeomic was a non-irritant substance.

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