- Zeomic and antimicrobial-related terminology
- Antimicrobial agent and antimicrobial test terminology
- Virus terminology
- Odor-eliminating test terminology
- Test terminology
- Approval/license and certification terminology
Terminology: Acute Toxicity Test (Mandatory SIAA test item)
For acute toxicity testing, there are oral toxicity tests, percutaneous toxicity tests, and respiratory toxicity tests. As a rule, the type of test conducted is selected based on the type of exposure the test substance may have.
This test administers a single dose or a repeated dose of the test substance to the test animals over a short period of time.
The symptoms, weight changes, physiological changes are examined at this time to elucidate the qualitative and quantitative toxicity characteristics of the test substance.
Using rats as test animals, 5000 mg/kg of the test substance was administered orally or 2000 mg/kg was administered subcutaneously. These tests were administered in compliance with the Pharmaceutical Affairs Bureau Bulletin 313: Standards for Good Laboratory Practices in Pharmaceutical Products Safety Tests.
Anything over 1500 mg/kg at LD50 is deemed a substance with low toxicity.
[Test Results for Zeomic]
No test animal showed weight decrease nor did even a single case of death occur with the oral administration test results. The LD50 was determined to be 5000 mg/kg or higher. Incidentally, the LD50 of sodium chloride is 3000 mg/kg. The LD50 for percutaneous administration was 2000 mg/kg or higher.